反応 #2139930

反応方程式

N,N-diphenylhydrazine hydrochloride

4-diethylamino-2-hydroxybenzaldehyde

sodium carbonate

→

4-Diethylamino-2-hydroxybenzaldehyde N,N-diphenylhydrazone

溶媒

ethanol

ethanol

反応条件

後処理

1. 1
   その他reacted in about ½ hour
2. 2
   その他The residue obtained
3. 3
   その他after evaporation of the solvent (800 ml)
4. 4
   workup.ADDITIONwas treated with ether
5. 5
   抽出the ether extract
6. 6
   洗浄was washed with water until the pH of the water
7. 7
   乾燥The organic layer was dried over anhydrous magnesium sulphate
8. 8
   workup.ADDITIONtreated with activated charcoal
9. 9
   ろ過filtered
10. 10
    その他The ether solvent was evaporated
11. 11
    その他the residue was recrystallized from ethanol
12. 12
    ろ過Crystalline 4-diethylamino-2-hydroxybenzaldehyde N,N-diphenylhydrazone was filtered off
13. 13
    洗浄washed with cold ethanol
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    その他to be 95.5-96.5° C.
15. 15
    その他recrystallized from a mixture of 2-propanol and ether in a 10:1 ratio by volume)
16. 16
    その他An elemental analysis yielded the
17. 17
    その他following results in weight percent

実験手順

A solution of N,N-diphenylhydrazine hydrochloride (79.5 g, 0.36 mol, from Aldrich, Milwaukee, Wis.) in ethanol (500 ml) was slowly added to a solution of 4-diethylamino-2-hydroxybenzaldehyde (58.0 g, 0.3 mol, from Aldrich, Milwaukee, Wis.) in ethanol (500 ml) in the presence of excess sodium carbonate. The reaction mixture was refluxed until all of the aldehyde reacted in about ½ hour. The residue obtained after evaporation of the solvent (800 ml) was treated with ether and the ether extract was washed with water until the pH of the water reached 7. The organic layer was dried over anhydrous magnesium sulphate, treated with activated charcoal, and filtered. The ether solvent was evaporated and the residue was recrystallized from ethanol. Crystalline 4-diethylamino-2-hydroxybenzaldehyde N,N-diphenylhydrazone was filtered off and washed with cold ethanol. The yield of the product was 85 g (78.8%). The melting point was found to be 95.5-96.5° C. (recrystallized from a mixture of 2-propanol and ether in a 10:1 ratio by volume). The 1H-NMR spectrum (100 MHz) of the product in CDCl3 was characterized by the following chemical shifts (δ, ppm): 11.55 (s, 1H, OH); 7.55-6.95 (m, 11H, CH═N, Ph); 6.7 (d, J=8.6 Hz; 1H, 6-H of 1,2,4-subst. Ph); 6.23 (s, 1H, 3-H of 1,2,4-subst. Ph); 6.1 (d, J=8.6 Hz, 1H, 5-H of 1,2,4-subst. Ph); 3.3 (q, J=8.0 Hz, 4H, CH2); 1.1 (t, J=8.0 Hz, 6H, CH3). An elemental analysis yielded the following results in weight percent: C, 76.68; H, 7.75; N, 11.45, which compared with calculated values for C23H25N3O in weight percent of: C, 76.85; H, 7.01; N, 11.69.

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