反応 #213975

ord-1627c269304c46a19ca80a57079f4f18

反応方程式

COC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C
Boc-Tyr-DAla-Phe-Met-OCH3
CCN
ethylamine
→
CCNC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C
Boc-Tyr-DAla-Phe-Met-NHCH2CH3
収率 92.0%

反応物

COC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C
Boc-Tyr-DAla-Phe-Met-OCH3
CCN
ethylamine

試薬

なし

溶媒

CO
methanol
CO
methanol

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

In a fashion analogous to Step D of Example 1A, 2.15 g of Boc-Tyr-DAla-Phe-Met-OCH3 was treated with 20 ml of ethylamine in 200 ml of methanol to give 2.01 g (92%) of Boc-Tyr-DAla-Phe-Met-NHCH2CH3, m.p. 159°-161° C., [α]D25 =5.04° (c, 0.97 in methanol).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US04254024uspto-grants-1981_03