反応 #213974

ord-0f0e7fbb41eb43c5a03cd3f0cbc32531

反応方程式

CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)O
Boc-Tyr-DAla-Phe-Met-OH
COc1ccccc1
anisole
→
CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)O
H-Tyr-DAla-Phe-Met-OH
収率 69.2%

反応物

CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)O
Boc-Tyr-DAla-Phe-Met-OH
COc1ccccc1
anisole

試薬

なし

溶媒

O=C(O)C(F)(F)F
TFA

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他chromatographed on Amberlite XAD-2

実験手順

In a fashion analogous to Step B of Example 3A, 1.1 g of Boc-Tyr-DAla-Phe-Met-OH was treated with 10% anisole in TFA and chromatographed on Amberlite XAD-2 to give 0.64 g (60%) of H-Tyr-DAla-Phe-Met-OH, m.p. 248°-249° C., [α]D25.5 =41.06° (c, 1.00 in 50% acetic acid).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US04254024uspto-grants-1981_03