反応 #2130

反応方程式

1-bromo-3-methylbutane

sodium hydride

3-methylxanthine

hydrogen

→

7-(3-Methylbutyl)-3-methylxanthine

溶媒

water

DMF

反応条件

後処理

1. 1
   ろ過The precipitate was filtered off with suction
2. 2
   洗浄washed with water
3. 3
   その他dried to constant weight

実験手順

100 g (0.602 mol) of 3-methylxanthine, dissolved in 1200 ml of DMF, were slowly treated with 16 g (0.66 mol) of sodium hydride. The solution was heated to 60° C. and, when the evolution of hydrogen was at an end, treated with 109 g (0.66 mol) of 1-bromo-3-methylbutane. The reaction mixture was stirred at 100° C. for 12 hours and introduced into 2000 ml of water. The precipitate was filtered off with suction, washed with water and dried to constant weight.

出典