反応 #2122537

反応方程式

(S)-benzyl 2-oxooxetan-3-ylcarbamate

pyrazole

→

(S)-2-(benzyloxycarbonylamino)-3-(1H-pyrazol-1-yl)propanoic acid

収率 37.7%

溶媒

CH3CN

反応条件

後処理

1. 1
   温度The mixture was cooled to rt overnight
2. 2
   ろ過the solid filtered

実験手順

A suspension of (S)-benzyl 2-oxooxetan-3-ylcarbamate (0.67 g, 3.03 mmol), and pyrazole (0.22 g, 3.29 mmol) in CH3CN (12 mL) was heated at 50° C. for 24 h. The mixture was cooled to rt overnight and the solid filtered to afford (S)-2-(benzyloxycarbonylamino)-3-(1H-pyrazol-1-yl)propanoic acid (330.1 mg). The filtrate was concentrated in vacuo and then triturated with a small amount of CH3CN (ca. 4 mL) to afford a second crop (43.5 mg). Total yield 370.4 mg (44%).

出典