反応 #2122533

反応方程式

ClCO2Me

(S)-2-amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acid

NaHCO3

→

HCl

title compound

(S)-2-(methoxycarbonylamino)-3-(1-methyl-1H-imidazol-4-yl)propanoic acid

反応条件

後処理

1. 1
   その他Cap-127 was prepared

実験手順

Cap-127 was prepared according to the method for Cap-126 above starting from (S)-2-amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acid (1.11 g, 6.56 mmol), NaHCO3 (1.21 g, 14.4 mmol) and ClCO2Me (0.56 mL, 7.28 mmol). The title compound was obtained as its HCl salt (1.79 g, >100%) contaminated with inorganic salts. LCMS and 1H NMR showed the presence of ca. 5% of the methyl ester. The crude mixture was used as is without further purification.

出典