反応 #2122520

反応方程式

Compound 24

N,N,2-trimethylbenzo[d]thiazole-6-sulfonamide

p-toluenesulfonic acid methyl ester

→

Compound 25

収率 84.0%

6-(N,N-dimethylsulfamoyl)-2,3-dimethylbenzo[d]thiazole-3-ium tosylate

収率 84.0%

反応条件

後処理

1. 1
   温度to cool to room temperature
2. 2
   その他the resulting mass was triturated with ethyl acetate (25 ml) until an off-white solid
3. 3
   その他separated
4. 4
   その他The solid was collected by centrifugation
5. 5
   洗浄washed with ethyl acetate
6. 6
   その他dried under vacuum

実験手順

A mixture of Compound 24 (2.0 g, 7.8 mmol) and p-toluenesulfonic acid methyl ester (2.2 g, 11.7 mmol) was heated in a pressure tube at 130° C. for 2 hours. The mixture was allowed to cool to room temperature, and the resulting mass was triturated with ethyl acetate (25 ml) until an off-white solid separated. The solid was collected by centrifugation, washed with ethyl acetate and dried under vacuum to yield 2.9 g (84%) of Compound 25 whose structure is given below:

出典