反応 #2122515

反応方程式

Chlorosulfonic acid

2-methylbenzoxazole

→

Compound 8

収率 59.9%

2-methylbenzoxazole-6-sulfonyl chloride

収率 59.9%

溶媒

反応条件

後処理

1. 1
   その他of 15 min
2. 2
   温度After cooling
3. 3
   workup.ADDITIONmix
4. 4
   その他The white solid that separated
5. 5
   ろ過was collected by filtration
6. 6
   洗浄washed with water until washings
7. 7
   その他dried

実験手順

Chlorosulfonic acid (12.5 ml, 187.8 mmol) was cooled in an ice bath and 2-methylbenzoxazole (5.0 g, 37.5 mmol) was carefully added drop wise over a period of 15 min. The combined mixture was heated at 115-120° C. for 16 hours. After cooling, the mixture was added very slowly to ca. 100 ml ice/water mix. The white solid that separated was collected by filtration, washed with water until washings were neutral and dried to yield 5.2 g (59%) of Compound 8, whose structure is given below:

出典