反応 #2122488

反応方程式

1-Methoxy-piperidin-4-ol

1-methoxy-piperidin-4-ol

triethylamine

Methanesulfonyl chloride

→

methanesulfonic acid 1-methoxy-piperidin-4-yl ester

収率 126.3%

溶媒

ethyl acetate

反応条件

後処理

1. 1
   workup.WAITat room temperature for an additional 1 hour
2. 2
   ろ過Then the mixture was filtered
3. 3
   その他the solvent evaporated

実験手順

21 g 1-Methoxy-piperidin-4-ol (from Step 1) and 19.4 g triethylamine were dissolved in 200 ml ethyl acetate, and cooled to 0° C. 15.0 g Methanesulfonyl chloride was added slowly. The resulting white suspension was stirred at 0° C. for 1 hour, then at room temperature for an additional 1 hour. Then the mixture was filtered and the solvent evaporated, yielding 34.6 g of methanesulfonic acid 1-methoxy-piperidin-4-yl ester. This material was used for the next step without further purification.

出典