反応 #2119

反応方程式

diethyl [4-(3-methylxanthin-1-yl)-butyl]phosphonate

ethyl iodide

potassium carbonate

→

Diethyl [4-(7-ethyl-3-methylxanthin-1-yl)butyl]phosphonate

溶媒

DMF

反応条件

後処理

1. 1
   ろ過The solid was filtered off
2. 2
   濃縮the filtrate was concentrated under reduced pressure
3. 3
   ろ過filtered again
4. 4
   その他crystallized from diisopropyl ether

実験手順

7.2 g (0.02 mol) of diethyl [4-(3-methylxanthin-1-yl)-butyl]phosphonate were suspended in 100 ml of DMF, treated with 4.7 g (0.03 mol) of ethyl iodide and 4.1 g (0.03 mol) of activated potassium carbonate and heated at 60° C. for 4 hours. The solid was filtered off, the filtrate was concentrated under reduced pressure and the oily residue which remained was taken up in ethyl acetate, filtered again and crystallized from diisopropyl ether.

出典