反応 #2116

反応方程式

benzylethyl 4-(7-ethoxymethyl-3-methylxanthin-1-yl)-butylphosphonate

ammonia

→

Monoethyl ammonium [4-(7-ethoxymethyl-3-methylxanthin-1-yl)butyl]-phosphonate

溶媒

ethanol

反応条件

後処理

1. 1
   ろ過The catalyst was filtered off
2. 2
   濃縮the filtrate was concentrated under reduced pressure
3. 3
   その他the solution obtained
4. 4
   その他after evaporating the solvent
5. 5
   その他was then crystallized from diisopropyl ether

実験手順

6.3 g (0.013 mol) of benzylethyl 4-(7-ethoxymethyl-3-methylxanthin-1-yl)-butylphosphonate were hydrogenated in 100 ml of ethanol over 0.5 g of palladium (10%) on active carbon at room temperature in the course of 4 hours. The catalyst was filtered off, the filtrate was concentrated under reduced pressure, the solution obtained was treated with methanolic ammonia and the residue which remained after evaporating the solvent was then crystallized from diisopropyl ether.

出典