反応 #2109

反応方程式

diethyl 5-hydroxypentylphosphonate

3,4-dihydropyran

pyridinium toluene-4-sulfonate

→

Diethyl 5-(tetrahydropyran-2-yloxy)pentylphosphonate

溶媒

dichloromethane

反応条件

後処理

1. 1
   温度under reflux for 16 hours
2. 2
   洗浄The solution was washed with water and saturated sodium hydrogen carbonate solution
3. 3
   乾燥dried over sodium sulfate
4. 4
   workup.DISTILLATIONdistilled in a bulb tube

実験手順

A solution of 66.9 g (0.298 mol) of diethyl 5-hydroxypentylphosphonate, 32.6 g (0.38 mol) of 3,4-dihydropyran and 1 g (0.004 mol) of pyridinium toluene-4-sulfonate in 800 ml of dichloromethane was heated under reflux for 16 hours. The solution was washed with water and saturated sodium hydrogen carbonate solution, dried over sodium sulfate and distilled in a bulb tube.

出典