反応 #2092

反応方程式

7-benzyl-3-methylxanthine

ethoxymethyl chloride

potassium carbonate

→

7-Benzyl-1-ethoxymethyl-3-methylxanthine

溶媒

dimethylformamide

反応条件

後処理

1. 1
   ろ過the mixture was filtered
2. 2
   濃縮concentrated
3. 3
   その他the residue which remained was chromatographed (eluent: dichloromethane/methanol 20:1)

実験手順

20 g (0.078 mol) of 7-benzyl-3-methylxanthine were stirred at 80° C. for 6 hours with 8.8 g (0.094 mol) of ethoxymethyl chloride and 13 g of potassium carbonate in 500 ml of absolute dimethylformamide, the mixture was filtered and concentrated, and the residue which remained was chromatographed (eluent: dichloromethane/methanol 20:1).

出典