反応 #2088

反応方程式

7-ethoxymethyl-3-methylxanthine

ethyl iodide

potassium carbonate

→

7-Ethoxymethyl-1-ethyl-3-methylxanthine

溶媒

DMF

反応条件

後処理

1. 1
   ろ過The solution was filtered
2. 2
   その他the residue which remained was crystallized in diisopropyl ether
3. 3
   その他28.7 g (85% of theory) of the title substance were obtained
4. 4
   その他employed without purification in Example 4b)

実験手順

30 g (0.134 mol) of 7-ethoxymethyl-3-methylxanthine were suspended in 500 ml of absolute DMF with 25 g (0.161 mol) of ethyl iodide and 22.2 g (0.161 mol) of potassium carbonate and the mixture was stirred at 70° C. for 5 hours. The solution was filtered and the residue which remained was crystallized in diisopropyl ether. 28.7 g (85% of theory) of the title substance were obtained and employed without purification in Example 4b).

出典