反応 #2087

反応方程式

diethyl [4-(1-benzyl-3-methylxanthin-7-yl)-butyl]phosphonate

ammonia

→

Diethyl [4-(3-methylxanthin-7-yl)butyl]phosphonate

溶媒

ethanol

反応条件

後処理

1. 1
   ろ過The catalyst was filtered off
2. 2
   その他the solvent was evaporated under reduced pressure
3. 3
   その他the residue which remained was crystallized from diisopropyl ether

実験手順

13 g (0.03 mol) of diethyl [4-(1-benzyl-3-methylxanthin-7-yl)-butyl]phosphonate were suspended in 150 ml of ethanol with 2 g of palladium on activated carbon (10%) and, after addition of 3 ml of concentrated ammonia solution, hydrogenated with shaking at 1.5 bar in the course of 48 hours. The catalyst was filtered off, the solvent was evaporated under reduced pressure and the residue which remained was crystallized from diisopropyl ether.

出典