反応 #2084

反応方程式

benzyl bromide

7-ethoxymethyl-3-methylxanthine

potassium carbonate

→

1-Benzyl-7-ethoxymethyl-3-methylxanthine

溶媒

dimethylformamide

反応条件

後処理

1. 1
   ろ過The reaction solution was filtered hot
2. 2
   濃縮the filtrate was concentrated under reduced pressure
3. 3
   その他the residue was dried to constant weight in a bulb tube at 1 mbar and 60° C.

実験手順

205 g (1.2 mol) of benzyl bromide were added to a suspension of 224 g (1 mol) of 7-ethoxymethyl-3-methylxanthine and 165 g of potassium carbonate in 1000 ml of dimethylformamide and the mixture was then stirred overnight at 90° C. The reaction solution was filtered hot, the filtrate was concentrated under reduced pressure and the residue was dried to constant weight in a bulb tube at 1 mbar and 60° C.

出典