反応 #2075692

反応方程式

3,3′-iminobispropylamine

ethyl trifluoroacetate

→

2,2,2-trifluoro-N-{3-[3-(2,2,2-trifluoroacetylamino)propylamino]propyl}acetamide

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   workup.ADDITIONAt the end of the addition (3 hours later), the reaction mixture
2. 2
   その他to return to room temperature
3. 3
   温度the stirring was maintained for a few hours under argon

実験手順

35 g of 3,3′-iminobispropylamine (266.7 mmol) were solubilized in 150 ml of anhydrous tetrahydrofuran under an argon stream. The reaction mixture was then cooled to 0° C. on an ice bath and 65 ml of ethyl trifluoroacetate (546.8 mmol) were added dropwise (very slowly) using a dropping funnel. At the end of the addition (3 hours later), the reaction mixture was allowed to return to room temperature and the stirring was maintained for a few hours under argon.

出典