反応 #2075690

反応方程式

3-aminopropan-1,2-diol

ethyl trifluoroacetate

→

pure colorless oil

収率 95.0%

N-(2,3-dihydroxypropyl)-2,2,2-trifluoroacetamide

収率 95.0%

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   その他provided with a magnetic bar
2. 2
   その他The crude reaction product
3. 3
   その他was then evaporated to dryness

実験手順

15 g of 3-aminopropan-1,2-diol (164.6 mmol) were solubilized in 100 ml of tetrahydrofuran in a round-bottomed flask provided with a magnetic bar. The reaction mixture was then cooled to 0° C. on an ice bath and 21.5 ml of ethyl trifluoroacetate (181.1 mmol) were gradually added. The reaction mixture was stirred for 2 hours at room temperature. The crude reaction product was then evaporated to dryness. 29 g of a pure colorless oil were thus obtained (yield: 95%), that product was used without further purification.

出典