反応 #2075010

反応方程式

3-bromo-dihydrofuran-2(3H)-one

(4-mercaptophenyl)methanol

triethylamine

→

product

収率 73.3%

3-(4-(hydroxymethyl)phenylthio)dihydrofuran-2(3H)-one

収率 73.3%

溶媒

CH2Cl2

反応条件

後処理

1. 1
   洗浄washed sequentially with saturated NH4Cl and NaCl solutions
2. 2
   乾燥The organics were dried over MgSO4
3. 3
   濃縮concentrated under reduced pressure

実験手順

3-bromo-dihydrofuran-2(3H)-one (2.35 g, 14.3 mmol) was added to a solution of (4-mercaptophenyl)methanol (2.00 g, 14.0 mmol) and triethylamine (2.4 mmol, 17 mmol). The reaction was stirred at room temperature overnight, then was diluted with CH2Cl2 and washed sequentially with saturated NH4Cl and NaCl solutions. The organics were dried over MgSO4 and concentrated under reduced pressure to provide the product as a viscous oil (2.3 g, 72%).

出典