反応 #2074941

反応方程式

1-(4-imidazol-1-ylphenyl)-piperazine

2,4,6,7-tetramethyl-5-nitrodihydrobenzofuran-2-carboxylic acid

1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

1-hydroxybenzotriazole hydrochloride

→

objective compound

収率 98.9%

(±)-(5-nitro-2,4,6,7-tetramethyldihydrobenzofuran-2-yl)-[4-(4-imidazol-1-ylphenyl)-piperazin-1-yl]carboxamide

収率 98.9%

溶媒

triethylamine

water

反応条件

後処理

1. 1
   その他the precipitated crystal was removed by filtration
2. 2
   洗浄washed with water and ether
3. 3
   その他the resulting crystal was dried

実験手順

To 0.43 g of 1-(4-imidazol-1-ylphenyl)-piperazine and 0.5 g of 2,4,6,7-tetramethyl-5-nitrodihydrobenzofuran-2-carboxylic acid, 0.44 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 0.31 g of 1-hydroxybenzotriazole hydrochloride and 0.23 g of triethylamine were added, followed by stirring at room temperature for 24 hours. The reaction solution was poured into water and the precipitated crystal was removed by filtration and washed with water and ether, and then the resulting crystal was dried to obtain 0.88 g of the objective compound.

出典