反応 #2069958

反応方程式

hydrobromic acid

compound

1-(4-Butylbenzyl)-6-methoxyisoquinoline

→

title compound

収率 94.6%

1-(4-Butylbenzyl)-6-isoquinolinol

収率 94.6%

反応条件

後処理

1. 1
   温度under reflux for 19 hours
2. 2
   濃縮The mixture was concentrated under reduced pressure, water
3. 3
   workup.ADDITIONwas added
4. 4
   その他to precipitate crystals
5. 5
   ろ過The obtained crystals were collected by filtration
6. 6
   洗浄washed with water
7. 7
   その他dried

実験手順

A 47% hydrobromic acid solution was added to the compound of Example B146 (82 mg), and the mixture was stirred under reflux for 19 hours. The mixture was concentrated under reduced pressure, water was added, and the resulting mixture was neutralized with sodium carbonate to precipitate crystals. The obtained crystals were collected by filtration, washed with water, and then dried to give the title compound (74 mg).

出典