反応 #2069949

反応方程式

Dimethylamine

triethylamine

1-(3-dimethylaminopropyl)-3-ethylcarbodiimide

4-pentynoic acid

→

title compound

N,N-dimethyl-4-pentynamide

溶媒

methylene chloride

反応条件

後処理

1. 1
   洗浄The reaction mixture was washed successively with 1 N hydrochloric acid
2. 2
   乾燥a saturated aqueous sodium hydrogencarbonate solution, water, and saturated brine, dried over anhydrous magnesium sulfate
3. 3
   濃縮concentrated under reduced pressure

実験手順

Dimethylamine (2 M solution in tetrahydrofuran, 8.53 ml), triethylamine (2.59 ml), and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (3221 mg), were added to a solution of 4-pentynoic acid (552 mg) in methylene chloride (150 ml) and this reaction mixture was stirred at room temperature for 24 hours. The reaction mixture was washed successively with 1 N hydrochloric acid, a saturated aqueous sodium hydrogencarbonate solution, water, and saturated brine, dried over anhydrous magnesium sulfate, then concentrated under reduced pressure to give the title compound (129 mg). The obtained compound was used in the following reaction without further purification.

出典