反応 #2069945

反応方程式

sodium hydrogencarbonate

Methanesulfonyl chloride

triethylamine

o-iodobenzyl alcohol

→

title compound

収率 100.7%

1-(Chloromethyl)-2-iodobenzene

収率 100.7%

溶媒

methylene chloride

反応条件

後処理

1. 1
   抽出the resulting mixture was extracted with methylene chloride
2. 2
   乾燥The methylene chloride layer was dried over anhydrous magnesium sulfate
3. 3
   濃縮concentrated under reduced pressure

実験手順

Methanesulfonyl chloride (2.0 ml, 29 mmol) and triethylamine (3.6 ml, 26 mmol) were added to a solution of o-iodobenzyl alcohol (5.0 g, 21 mmol) in methylene chloride (50 ml) cooled to 0° C., and the mixture was stirred at that temperature for 19 hours. A 5% aqueous sodium hydrogencarbonate solution was added, and the resulting mixture was extracted with methylene chloride. The methylene chloride layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give the title compound (5.34 g).

出典