反応 #2069939

反応方程式

3-(2-naphthalen-2-yl-propionylamino)-4,6-dihydro-pyrrolo[3,4-c]pyrazole-1,5-dicarboxylic acid 5-tert-butyl ester 1-ethyl ester

TFA DCM

→

title compound

収率 101.6%

3-(2-Naphthalen-2-yl-propionylamino)-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid ethyl ester

収率 101.6%

溶媒

DCM

反応条件

後処理

1. 1
   その他evaporated to dryness
2. 2
   workup.DISSOLUTIONThe resulting residue was dissolved in DCM
3. 3
   洗浄the solution was washed with brine
4. 4
   workup.ADDITIONtreated with NaHCO3 aq. The obtained precipitate
5. 5
   ろ過was filtered
6. 6
   洗浄washed with water and DCM
7. 7
   その他dried under vacuum

実験手順

2.5 g (5.2 mmol) of 3-(2-naphthalen-2-yl-propionylamino)-4,6-dihydro-pyrrolo[3,4-c]pyrazole-1,5-dicarboxylic acid 5-tert-butyl ester 1-ethyl ester in 15 ml DCM was treated with 16 ml of (1:1) TFA/DCM. The reaction mixture was stirred for 30 min. and evaporated to dryness. The resulting residue was dissolved in DCM and the solution was washed with brine and then treated with NaHCO3 aq. The obtained precipitate was filtered, washed with water and DCM, and then dried under vacuum to give 2.0 g (quantitative yield) of the title compound.

出典