反応 #2063062

反応方程式

4-(3,4-dichlorophenyl)-1-piperazineethanamine

4-methyl-1-isothiocyanatobenzene

→

N-(4-methylphenyl)-N′-[2-[4-(3,4-dichlorophenyl)-1-piperazinyl]ethyl]thiourea

収率 99.2%

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   その他The solvent was evaporated
2. 2
   その他The residue was recrystallized from DIPE
3. 3
   ろ過The precipitate was filtered off
4. 4
   その他dried
5. 5
   その他The product was used without further purification

実験手順

A mixture of 4-(3,4-dichlorophenyl)-1-piperazineethanamine (0.01 mol) and 4-methyl-1-isothiocyanatobenzene (0.01 mol) in tetrahydrofuran (300 ml) was stirred at room temperature for 1 hour. The solvent was evaporated. The residue was recrystallized from DIPE. The precipitate was filtered off and dried. The product was used without further purification, yielding 4.2 g N-(4-methylphenyl)-N′-[2-[4-(3,4-dichlorophenyl)-1-piperazinyl]ethyl]thiourea (interm. 6).

出典