反応 #2060414

反応方程式

chloroacetyl chloride

2,6-dimethyl-3-aminopyridine

pyridine

→

N-(2,6-dimethyl-3-pyridyl)-α-chloroacetamide

溶媒

ether

反応条件

後処理

1. 1
   その他equipped with mechanical stirrer
2. 2
   workup.ADDITIONthermometer and addition funnel
3. 3
   workup.ADDITIONis slowly added over a period of about 15 minutes
4. 4
   温度cooling
5. 5
   その他the completion of the reaction
6. 6
   ろ過The resulting precipitate is then recovered by filtration
7. 7
   洗浄is washed with aqueous potassium carbonate and with water
8. 8
   その他is dried

実験手順

A solution of 2,6-dimethyl-3-aminopyridine (24.9 grams) in ether (200 ml), and pyridine (21 grams) are charged into a glass reaction vessel equipped with mechanical stirrer, thermometer and addition funnel. The reaction mixture is cooled to a temperature below about 10° C and chloroacetyl chloride (11.3 grams) is slowly added over a period of about 15 minutes. Stirring and cooling is continued for an additional period of about 1 hour to ensure the completion of the reaction. The resulting precipitate is then recovered by filtration, is washed with aqueous potassium carbonate and with water, and is dried to yield the desired product N-(2,6-dimethyl-3-pyridyl)-α-chloroacetamide.

出典