反応 #2050900

反応方程式

4-(2-chloro-5-nitrophenyl)-3-fluoropyridine

sodium carbonate

→

4-chloro-3-(3-fluoropyridin-4-yl)benzenamine

溶媒

acetic acid

反応条件

後処理

1. 1
   その他Reaction
2. 2
   ろ過filtered
3. 3
   その他to remove iron
4. 4
   その他Reaction
5. 5
   その他partitioned between ethyl acetate and water
6. 6
   その他Organic layer separated
7. 7
   洗浄washed with brine
8. 8
   乾燥dried over sodium sulfate
9. 9
   濃縮concentrated

実験手順

4-(2-chloro-5-nitrophenyl)-3-fluoropyridine (1 eq) was stirred with Iron (0), (3 eq), in acetic acid for 10 hours at room temperature. Reaction neutralized with sodium carbonate and filtered to remove iron. Reaction partitioned between ethyl acetate and water. Organic layer separated and washed with brine, dried over sodium sulfate and concentrated to give 4-chloro-3-(3-fluoropyridin-4-yl)benzenamine. HPLC=1.72 min; MS: MH+=223.

出典