反応 #2045054

反応方程式

2-[4-(6-Benzyloxyhexanoylamino)phenoxy]propionic acid methyl ester

→

79

収率 51.6%

2-[4-(6-Hydroxyhexanoylamino)phenoxy]propionic acid methyl ester

収率 51.6%

溶媒

methanol

反応条件

後処理

1. 1
   その他Catalyst was removed by filtration and methanol
2. 2
   workup.DISTILLATIONdistilled off
3. 3
   その他The crude 79 was purified by column chromatography on silica gel

実験手順

2-[4-(6-Benzyloxyhexanoylamino)phenoxy]propionic acid methyl ester 78 (15 g, 37.59 mmol) was dissolved in methanol (150 ml) in a pressure vessel, palladium on carbon (50% wet, 5%, 15 g) added and the mixture stirred under a hydrogen atmosph. (4 Kg) for 16 hrs. Catalyst was removed by filtration and methanol distilled off. The crude 79 was purified by column chromatography on silica gel using chloroform as eluant to get pure 79 (6 g, 51.6%) as a white powder. M.p: 62-64.5° C.

出典