反応 #2045047

反応方程式

4-(2-Benzyloxyacetylamino)-phenoxyacetic acid methyl ester

4-(2-Benzyloxyacetylamino)phenoxyacetic acid methyl ester

→

67

収率 77.0%

4-(2-Hydroxyacetylamino)phenoxyacetic acid methyl ester

収率 77.0%

溶媒

methanol

反応条件

後処理

1. 1
   その他Catalyst was removed by filtration and methanol
2. 2
   workup.DISTILLATIONdistilled off
3. 3
   その他Crude 67 was recrystallised in chloroform:hexane (1:6)

実験手順

4-(2-Benzyloxyacetylamino)-phenoxyacetic acid methyl ester 66 (25 g, 76 mmol) was dissolved in methanol (450 ml) in a pressure vessel, palladium on carbon (5%, 10 g) added and the mixture stirred under a hydrogen atm. (2 Kg) for 5 hrs. Catalyst was removed by filtration and methanol distilled off. Crude 67 was recrystallised in chloroform:hexane (1:6) to give pure 67 (14 g) as a white powder. M.p: 147.5-150° C.

出典