反応 #2045039

反応方程式

6-(4-nitrophenoxy) hexanoic acid methyl ester

6-(4-Nitro-phenoxy)-hexanoic acid methyl ester

→

53

収率 80.2%

6-(4-Nitrophenoxy)-hexanoic acid

収率 80.2%

溶媒

HCl

反応条件

後処理

1. 1
   温度was refluxed for 16 hours
2. 2
   ろ過filtered
3. 3
   その他dried
4. 4
   その他recrystallised from a mixture of ethyl acetate:hexane (1:6)

実験手順

A mixture of 6-(4-nitrophenoxy) hexanoic acid methyl ester 39 (125 g, 468.16 mmol) and concentrated HCl (1250 ml) was refluxed for 16 hours. The reaction mixture was cooled to room temperature, filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:6) to get pure 53 (95 g, 80.2%) as a white powder. M.p: 104-107° C.

出典