反応 #2045033

反応方程式

(4-Aminophenoxy)acetic acid methyl ester

(4-Nitro-phenoxy)-acetic acid-2-hydroxy-ethyl ester

→

46

収率 22.8%

(4-Amino-phenoxy)-acetic acid 2-hydroxy-ethyl ester

収率 22.8%

溶媒

ethyl acetate

反応条件

後処理

1. 1
   その他The catalyst was removed by filtration, ethyl acetate
2. 2
   workup.DISTILLATIONwas distilled off
3. 3
   workup.ADDITIONhexane was added
4. 4
   ろ過The solid product was filtered
5. 5
   その他dried

実験手順

(4-Aminophenoxy)acetic acid methyl ester 41 (1 g, 4.15 mmol) was dissolved in ethyl acetate in a pressure vessel, palladium on carbon (5%, 0.5 g) was added and the mixture was stirred under an atmosphere of hydrogen (0.5 Kg) for one hour. The catalyst was removed by filtration, ethyl acetate was distilled off and hexane was added. The solid product was filtered and dried to give pure 46 (0.2 g, 22.8%) as a brown powder. M.p: 104-106.3° C.

出典