反応 #2045028

反応方程式

methyl(4-nitrophenoxy)acetate

Methyl(4-Nitro phenoxy)acetate

→

40

収率 92.1%

(4-Nitro phenoxy)acetic acid

収率 92.1%

溶媒

HCl

反応条件

後処理

1. 1
   温度was refluxed for 8 hours
2. 2
   ろ過Crude 40 was filtered
3. 3
   その他dried
4. 4
   その他recrystallised from a mixture of ethyl acetate:hexane (1:5)

実験手順

A mixture of methyl(4-nitrophenoxy)acetate 31 (100 g, 474 mmol) and concentrated HCl (1000 ml) was refluxed for 8 hours. The reaction mass was cooled to room temp. Crude 40 was filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:5) to give pure 40 (86 g, 92.1%) as a white shining powder. M.p: 186-188.5° C.

出典