反応 #2045025

反応方程式

6-(4-Isocyanato-phenoxy)-hexanoic acid methyl ester

ethylene glycol

→

37

収率 84.0%

6-[4-(2-Hydroxy-ethoxycarbonylamino)-phenoxy]-hexanoic acid methyl ester

収率 84.0%

溶媒

Water

反応条件

後処理

1. 1
   その他rose to 46° C
2. 2
   ろ過crude 37 was filtered
3. 3
   その他dried
4. 4
   その他recrystallised from toluene

実験手順

6-(4-Isocyanato-phenoxy)-hexanoic acid methyl ester 36 (15 g, 57 mmol) was added to ethylene glycol (50 ml) at room temperature. The reaction was exothermic and the temperature rose to 46° C. The reaction mixture was allowed to cool to room temperature and later stirred at room temperature for 16 hours. Water (150 ml) was added and crude 37 was filtered, dried and recrystallised from toluene to get pure 37 (12 g, 84%) as a white powder. M.p: 69.5-71.5° C.

出典