反応 #2045018

反応方程式

(4-Isocyanato-phenoxy)-acetic acid methyl ester

ethylene glycol

→

29

収率 82.9%

[4-(2-Hydroxy-ethoxycarbonylamino)-phenoxy]-acetic acid methyl ester

収率 82.9%

溶媒

Water

反応条件

後処理

1. 1
   ろ過crude 29 was filtered
2. 2
   その他dried
3. 3
   その他purified by column chromatography on silica gel

実験手順

(4-Isocyanato-phenoxy)-acetic acid methyl ester 28 (15 g, 72.46 mmol) was added to ethylene glycol (30 ml) at room temperature. The reaction was exothermic and the temperature raised to 42° C. Later the reaction mixture was stirred at room temperature for 16 hours. Water (100 ml) was added and crude 29 was filtered, dried and purified by column chromatography on silica gel using chloroform as eluant to get pure 29 (16.17 g, 82.9%) as a off-white powder. M.p: 85.5-87.5° C.

出典