反応 #2045014

反応方程式

Benzyloxyacetic acid 4-acetylamino-phenyl ester

Benzyloxy-acetic acid 4-acetylamino-phenyl ester

→

25

収率 57.4%

Hydroxy-acetic acid 4-acetylamino-phenyl ester

収率 57.4%

溶媒

methanol

反応条件

後処理

1. 1
   その他The catalyst was removed by filtration
2. 2
   workup.DISTILLATIONthe methanol was then distilled off
3. 3
   その他The crude 25 was recrystallized from mixture of chloroform:methanol (1:4)

実験手順

Benzyloxyacetic acid 4-acetylamino-phenyl ester 24 (15 g, 50 mmol) was dissolved in methanol (150 ml) in a pressure vessel, palladium on carbon (5%, 8 grams) added and the mixture stirred under an atmosphere of hydrogen (3 Kg) for 20 hours. The catalyst was removed by filtration and the methanol was then distilled off. The crude 25 was recrystallized from mixture of chloroform:methanol (1:4) to get pure 25 (6 g, 57.2%) as a white powder. M.p: 144-146° C.

出典