反応 #2045013

反応方程式

[2-(4-Nitrophenoxy)-ethoxy]acetic acid methyl ester

→

23

収率 71.1%

[2-(4-Amino-phenoxy)-ethoxy]-acetic acid methyl ester

収率 71.1%

溶媒

ethyl acetate

反応条件

後処理

1. 1
   ろ過The catalyst was filtered
2. 2
   濃縮the filtrate concentrated
3. 3
   workup.ADDITIONhexane (3 ml) added
4. 4
   ろ過the solid filtered

実験手順

[2-(4-Nitrophenoxy)-ethoxy]acetic acid methyl ester 22 (1 g, 3.9 mmol) was dissolved in anhydrous ethyl acetate (20 ml), palladium carbon (10%, 0.1 g) added and the mixture stirred under an atmosphere of hydrogen using balloon for 30 minutes. The catalyst was filtered, the filtrate concentrated, hexane (3 ml) added, and the solid filtered to give 23 (625 mg, 70.9%) as a light brown powder. The melting point was found to be 51-52.5° C. The structure was confirmed with IR and NMR.

出典