反応 #2045010

反応方程式

6-(4-Acetylaminophenoxy)hexanoic acid methyl ester

6-(4-Acetylamino-phenoxy)-hexanoic acid methyl ester

hydrochloric acid

→

20

収率 55.6%

6-(4-Amino-phenoxy)-hexanoic acid Hydrochloride

収率 55.6%

反応条件

後処理

1. 1
   温度was refluxed for 48 hours
2. 2
   workup.DISTILLATIONExcess concentrated hydrochloric acid was distilled off in vacuum
3. 3
   ろ過filtered hot
4. 4
   ろ過filtered
5. 5
   その他dried

実験手順

A mixture of 6-(4-Acetylaminophenoxy)hexanoic acid methyl ester 19 (290 grams, 1.04 mol) in concentrated hydrochloric acid (7.12 L) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried give pure 20 (150 g, 55.6%) as a brown powder. The melting point was found to be 155-160° C.

出典