反応 #2045007

反応方程式

2-(4-Acetylaminophenoxy)propionic acid methyl ester

2-(4-Acetylamino-phenoxy)-propionic acid methyl ester

→

17

収率 98.1%

2-(4-Amino-phenoxy)-propionic acid

収率 98.1%

溶媒

hydrochloric acid

反応条件

後処理

1. 1
   温度was refluxed for 48 hours
2. 2
   workup.DISTILLATIONExcess concentrated hydrochloric acid was distilled off in vacuum
3. 3
   ろ過filtered hot
4. 4
   ろ過filtered
5. 5
   その他dried

実験手順

A mixture of 2-(4-Acetylaminophenoxy)propionic acid methyl ester 16 (320 grams, 1.35 mol) in concentrated hydrochloric acid (8 liters) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 17 (240 g, 81.7%) as a brown powder. The melting point was found to be 175-180° C.

出典