反応 #2045004

反応方程式

(4-Acetylamino-phenoxy)-acetic acid ethyl ester

hydrochloric acid

→

14

収率 77.6%

(4-Amino-phenoxy)acetic acid HCl

収率 77.6%

反応条件

後処理

1. 1
   workup.DISTILLATIONExcess concentrated hydrochloric acid was distilled off in vacuum
2. 2
   ろ過filtered hot
3. 3
   ろ過filtered
4. 4
   その他dried

実験手順

A mixture (4-Acetylamino-phenoxy)-acetic acid ethyl ester 13 (375 g, 1.582 mmol), in concentrated hydrochloric acid (9.36 liters) was refluxed for 12 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 14 (250 g, 77.6%) as a wheat colored powder. The melting point was found to be 224-226° C. The structure was confirmed with NMR.

出典