反応 #2041001

反応方程式

sodium methoxide

ethanol

ethyl 2-(N,N-dimethylamino)-propionate

ethyl 2-(N,N-dimethylamino)-propionate

1-dodecanol

→

DDAIP

溶媒

toluene

反応条件

後処理

1. 1
   温度was refluxed for about 2 hours
2. 2
   その他it was removed by azeotropic distillation
3. 3
   温度After about 2 hours of refluxing
4. 4
   その他the remaining reaction product
5. 5
   ろ過was filtered
6. 6
   その他to remove solids

実験手順

DDAIP was prepared by transesterification of ethyl 2-(N,N-dimethylamino)-propionate obtained from Varsal Instruments Inc. (Warminster, Pa). Specifically, a mixture ethyl 2-(N,N-dimethylamino)-propionate, 1-dodecanol, and sodium methoxide predissolved in toluene was refluxed for about 2 hours. As ethanol formed, it was removed by azeotropic distillation. After about 2 hours of refluxing, the remaining reaction product was filtered to remove solids.

出典