反応 #2041000

反応方程式

ethyl 2-(N,N-dimethylamino)-propionate

1-dodecanol

sodium methoxide

→

DDAIP

溶媒

ethanol

反応条件

後処理

1. 1
   その他A representative reaction scheme
2. 2
   その他is removed from the reaction medium by azeotropic distillation
3. 3
   ろ過the solids of the remaining mixture are filtered off

実験手順

A representative reaction scheme follows: ##STR6## The ethyl 2-(N,N-dimethylamino)-propionate is preferably refluxed for about 2 hours in the presence of 10 percent stoichiometric excess 1-dodecanol and a catalytic amount of sodium methoxide (predissolved in toluene). During this process, the ethanol formed is removed from the reaction medium by azeotropic distillation. Following the reaction phase, the solids of the remaining mixture are filtered off, resulting in a DDAIP filtrate.

出典