反応 #2030122

反応方程式

Compound 24

N,N,2-trimethylbenzo[d]thiazole-6-sulfonamide

1-4-butane sultone

→

Compound 26

収率 92.0%

4-(6-(N.N-dimethylsulfamoyl)-2-methylbenzo[d]thiazole-3-ium-3-yl)butane-1-sulfonate

収率 92.0%

反応条件

後処理

1. 1
   温度to cool to room temperature
2. 2
   その他the resulting mass was triturated with ethyl acetate (40 ml) until a pink solid
3. 3
   その他separated
4. 4
   その他The solid was collected by centrifugation
5. 5
   洗浄washed with ethyl acetate
6. 6
   その他dried under vacuum

実験手順

A mixture of Compound 24 (2.55 g, 10.0 mmol) from step (a) of Example 27 and 1-4-butane sultone (2.98 g, 21.9 mmol) was heated in a pressure tube at 160° C. for 17 hours. The mixture was allowed to cool to room temperature, and the resulting mass was triturated with ethyl acetate (40 ml) until a pink solid separated. The solid was collected by centrifugation, washed with ethyl acetate and dried under vacuum to yield 3.58 g (92%) of Compound 26 with the structure:

出典