反応 #2028896

反応方程式

HCl

caprolactone

Caprolactone

potassium hydroxide

methanol

→

6-hydroxyhexanoic acid

溶媒

THF

反応条件

後処理

1. 1
   抽出extracted with ethyl acetate
2. 2
   洗浄The combined organic layers were washed with water
3. 3
   その他dried
4. 4
   ろ過filtered
5. 5
   濃縮concentrated

実験手順

First, the synthesis of Compound 20 was preformed following the procedure reported in PCT/JP2005/004389. 6-Hydroxyhexanoic acid was synthesized by base hydrolysis of caprolactone. Caprolactone (100 g) was added to a mixture of potassium hydroxide (145 g), methanol (110 mL), and THF (390 mL). The resulting mixture was stirred at room temperature overnight. The solution was then acidified with HCl and extracted with ethyl acetate. The combined organic layers were washed with water, dried, filtered, and concentrated to obtain 6-hydroxyhexanoic acid. 1H NMR (CDCl3, 500 MHz) δ 1.44 (m, 2H), 1.60 (m, 2H), 1.68 (m, 2H), 2.37 (t, J=7.5 Hz, 2H), 3.66 (t, J=6.5 Hz, 2H), 5.80 (br, 1H).

出典