反応 #2028892

反応方程式

compound

4-[4-bromomethyl-5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

collidine

dimethyl sulfoxide

→

desired product

収率 66.0%

4-[4-formyl-5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

収率 66.0%

反応条件

後処理

1. 1
   その他The reaction solution was partitioned between ethyl acetate and water
2. 2
   洗浄the organic solution was washed with water
3. 3
   その他dried
4. 4
   濃縮concentrated
5. 5
   その他The residue was chromatographed (1:1 hexane:ethyl acetate)

実験手順

To a solution of the compound prepared in Step 1 (362 mg, 0.79 mmol) in dimethyl sulfoxide (7 mL) was added collidine (0.14 mL, 1.0 mmol). The solution was heated at 120° C. for 3 hours and then kept at overnight at room temperature. The reaction solution was partitioned between ethyl acetate and water and the organic solution was washed with water, dried and concentrated. The residue was chromatographed (1:1 hexane:ethyl acetate) to give the desired product (205 mg, 66%).

出典