反応 #2028891

反応方程式

4-[4-methyl-5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

N-bromosuccinimide

→

desired product

4-[4-bromomethyl-5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

溶媒

carbon tetrachloride

benzene

反応条件

後処理

1. 1
   その他The mixture was irradiated with a sunlamp for 3.5 hours
2. 2
   その他The reaction mixture was partitioned between dichloromethane and water
3. 3
   その他the organic solution was dried
4. 4
   濃縮concentrated

実験手順

To a solution of 4-[4-methyl-5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide prepared in Example 201 (500 mg, 1.3 mmol) in carbon tetrachloride (9 mL) and benzene (4 mL) was added N-bromosuccinimide (285 mg, 1.6 mmol). The mixture was irradiated with a sunlamp for 3.5 hours. The reaction mixture was partitioned between dichloromethane and water and the organic solution was dried and concentrated to give the desired product, 412 mg (69%).

出典