反応 #2028887

反応方程式

hydrochloric acid

Ethyl formate

4′-chloroacetophenone

Sodium methoxide

→

yellow oil

収率 100.2%

3-[4-(chloro)phenyl]-propane-1,3-dione

収率 100.2%

溶媒

ether

反応条件

後処理

1. 1
   その他The phases were separated
2. 2
   洗浄the ethereal solution washed with brine
3. 3
   乾燥dried over magnesium sulfate
4. 4
   ろ過filtered
5. 5
   濃縮concentrated in vacuo

実験手順

Ethyl formate (8.15 g, 0.11 mol) and 4′-chloroacetophenone (15.4 g, 0.1 mol) were stirred in ether (150 mL) at room temperature. Sodium methoxide (25%) (23.77 g, 0.11 mol) was added dropwise. The mixture was stirred at room temperature for 16 hours and was then treated with 150 mL of 1N hydrochloric acid. The phases were separated and the ethereal solution washed with brine, dried over magnesium sulfate, filtered and concentrated in vacuo to afford 18.3 g of a yellow oil. The resulting crude mixture was used directly in the next step without purification.

出典