反応 #2028884

反応方程式

HCl

sodium methoxide

Ethyl trifluoroacetate

6-methyltetralone

→

oil

収率 85.1%

6-methyl-2-(trifluoroacetyl)tetralone

収率 85.1%

溶媒

ether

反応条件

後処理

1. 1
   その他The organic layer was collected
2. 2
   洗浄washed with brine
3. 3
   乾燥dried over MgSO4
4. 4
   濃縮concentrated in vacuo

実験手順

Ethyl trifluoroacetate (5.33 g, 37.5 mmol) was dissolved in ether (50 mL) and treated with a sodium methoxide solution (25% in methanol, 9.92 g, 45.9 mmol) followed by 6-methyltetralone (5.94 g, 37.1 mmol). The reaction was stirred at room temperature for 6.1 hours then treated with 1N HCl (20 mL). The organic layer was collected, washed with brine, dried over MgSO4, and concentrated in vacuo to give a brown oil (8.09 g) that was used in the next step without further purification.

出典