反応 #2025291

反応方程式

sodium hydride

hexyl p-toluenesulfonate

dimethylformamide

(+)-2-{4-(1-hydroxyethyl)phenyl}-5-decyloxypyrimidine

→

(+)-2-{4-(1-hexyloxyethyl)phenyl}-5-decyloxypyrimidine

収率 82.1%

溶媒

water

反応条件

後処理

1. 1
   その他to subject to reaction at the same temperature for 2 hours
2. 2
   その他After completion of the reaction
3. 3
   抽出extracted with 200 ml of toluene
4. 4
   その他followed by separation
5. 5
   洗浄the organic phase was washed with water sufficiently
6. 6
   乾燥by drying over anhydrous magnesium sulfate
7. 7
   workup.DISTILLATIONAfter the solvent was distilled off under reduced pressure
8. 8
   その他the resulting residue was purified by silica gel column chromatography (eluent; toluene:ethyl acetate)

実験手順

Into 20 ml of anhydrous dimethylformamide were dissolved 1.78 g (5 millimole) of the (+)-2-{4-(1-hydroxyethyl)phenyl}-5-decyloxypyrimidine obtained in Preparation Example [starting material compound (VI)] 70, and then 0.24 g (6 millimole) of 60% sodium hydride was added thereto, followed by stirring at 40° C. for 1 hour. Subsequently, 1.79 g (7 millimole) of hexyl p-toluenesulfonate were added thereto, to subject to reaction at the same temperature for 2 hours. After completion of the reaction, the reaction mixture was poured into 200 ml of water, extracted with 200 ml of toluene, followed by separation thereof, and the organic phase was washed with water sufficiently, followed by drying over anhydrous magnesium sulfate. After the solvent was distilled off under reduced pressure, the resulting residue was purified by silica gel column chromatography (eluent; toluene:ethyl acetate) to obtain 1.81 g (yield: 82%) of (+)-2-{4-(1-hexyloxyethyl)phenyl}-5-decyloxypyrimidine.

出典