反応 #2025290

反応方程式

sodium borohydride

ethanol

chloroform

2-(4-acetylphenyl)-5-decyloxypyrimidine

→

2-{4-(1-hydroxyethyl)phenyl}-5-decyloxypyrimidine

収率 99.9%

溶媒

water

反応条件

後処理

1. 1
   温度while maintaining the temperature at 30° to 35° C.
2. 2
   抽出extracted with 400 ml of ethyl acetate
3. 3
   洗浄The organic phase was washed sufficiently
4. 4
   乾燥dried over anhydrous magnesium sulfate
5. 5
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure

実験手順

To a mixed solvent of 200 ml of ethanol and 100 ml of chloroform were added 35.5 g (0.1 mole) of 2-(4-acetylphenyl)-5-decyloxypyrimidine, and while maintaining the temperature at 30° to 35° C., 2.65 g (0.07 mole) of sodium borohydride were gradually added thereto. After stirring at the same temperature for 4 hours, the reaction mixture was poured into 500 ml of water and extracted with 400 ml of ethyl acetate. The organic phase was washed sufficiently, dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure to obtain 35.6 g (yield: 99.9 %) of 2-{4-(1-hydroxyethyl)phenyl}-5-decyloxypyrimidine.

出典