反応 #2025288

反応方程式

(-)-4-acetoxy-4'-(3-propoxybutyl)biphenyl

NaOH

hydrochloric acid

→

4-hydroxy-4'-(3-propoxybutyl)biphenyl

収率 101.5%

溶媒

methanol

反応条件

後処理

1. 1
   workup.ADDITIONadded
2. 2
   その他After completion of the reaction
3. 3
   workup.ADDITIONfurther added
4. 4
   抽出with 100 ml of ethyl acetate, and thereafter subjected to extraction treatment
5. 5
   洗浄washed
6. 6
   濃縮concentrated under a reduced pressure

実験手順

2.6 g (8 mM) of the thus-obtained (-)-4-acetoxy-4'-(3-propoxybutyl)biphenyl was dissolved in 50 ml of methanol, added thereto with 10 ml of 20% NaOH aqueous solution, and then stirred at room temperature for 2 hrs. After completion of the reaction, the reaction mixture was made to pH 2-3 by adding 1N hydrochloric acid, and then further added thereto with 100 ml of ethyl acetate, and thereafter subjected to extraction treatment. The resulting organic layer was water-washed, and then concentrated under a reduced pressure to obtain 2.3 g of 4-hydroxy-4'-(3-propoxybutyl)biphenyl (V-47) with 100% yield

出典